Journal of Bodywork and Movement Therapies
Volume 12, Issue 3 , Pages 191-193, July 2008

Fibroblast mechanics in three-dimensional collagen matrices

Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines blvd., Dallas, TX 75390-9039, USA

Received 28 March 2008; accepted 30 March 2008.

Summary 

Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell–matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.

Keywords: Fascia, Tension, Contraction, Migration, Growth factor, Regulation

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PII: S1360-8592(08)00063-6

doi:10.1016/j.jbmt.2008.03.005

Journal of Bodywork and Movement Therapies
Volume 12, Issue 3 , Pages 191-193, July 2008

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