Journal of Bodywork and Movement Therapies
Volume 12, Issue 3 , Pages 185-190 , July 2008

Epi-perineurial anatomy, innervation, and axonal nociceptive mechanisms

  • Geoffrey M. Bove

      Affiliations

    • Corresponding Author InformationCorresponding author. Present address: Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Dana 721, Boston, MA 02215, USA. Tel.: +16176670641; fax: +16176671500.

Received 3 March 2008 ,Revised 26 March 2008 ,Accepted 30 March 2008.

References 

  1. Armstrong BD, et al. Induction of neuropeptide gene expression and blockade of retrograde transport in facial motor neurons following local peripheral nerve inflammation in severe combined immunodeficiency and BALB/C mice. Neuroscience. 2004;129:93–99
  2. Asbury AK, Fields HL. Pain due to peripheral nerve damage: an hypothesis. Neurology. 1984;34:1587–1590
  3. Bove GM, Light AR. Calcitonin gene-related peptide and peripherin immunoreactivity in nerve sheaths. Somatosensory and Motor Research. 1995;12:49–57
  4. Bove GM, Light AR. Unmyelinated nociceptors of rat paraspinal tissues. Journal of Neurophysiology. 1995;73:1752–1762
  5. Bove GM, et al. Inflammation induces ectopic mechanical sensitivity in axons of nociceptors innervating deep tissues. Journal of Neurophysiology. 2003;90:1949–1955
  6. Butler DS. The Sensitive Nervous System. Adelaide: Noigroup Publications; 2000;
  7. Chen Y, Devor M. Ectopic mechanosensitivity in injured sensory axons arises from the site of spontaneous electrogenesis. European Journal of Pain. 1998;2:165–178
  8. Dilley A, Bove GM. Resolution of inflammation induced axonal mechanical sensitivity and conduction slowing in C-fiber nociceptors. Journal of Pain. 2008;9:185–192
  9. Dilley A, Bove GM. Disruption of axoplasmic transport induces mechanical sensitivity in intact rat C-fibre nociceptor axons. Journal of Physiology. 2008;586:593–604
  10. Eliav E, et al. Neuropathic pain from an experimental neuritis of the rat sciatic nerve. Pain. 1999;83:168–182
  11. Horsley V. Preliminary communication on the existence of sensory nerves in nerve-trunks, true “nervi nervorum”. British Medical Journal. 1884;1:196–198
  12. Hromada J. On the nerve supply of the connective tissue of some peripheral nervous tissue system components. Acta Anatomica. 1963;55:343–351
  13. Koschorke GM, et al. Cellular components necessary for mechanoelectrical transduction are conveyed to primary afferent terminals by fast axonal transport. Brain Research. 1994;641:99–104
  14. Lembeck F. Sir Thomas Lewis's nocifensor system, histamine and substance-P-containing primary afferent nerves. Trends in Neurosciences. 1983;6:106–108
  15. Light AR. “Nocifensor” system re-revisited. Focus on “Two types of C nociceptor in human skin and their behavior in areas of capaicin-induced secondary hyperalgesia”. Journal of Neurophysiology. 2004;91:2401–2403
  16. Lundborg G. Nerve Injuries and Repair. Edinburgh: Churchill Livingstone; 1988;
  17. Sappey MC. Recherches sur les nerfsdu névrilème ou nervi nervorum. C. R. Acad. Sci. 1867;65:761–762
  18. Sauer SK, et al. Rat peripheral nerve components release calcitonin gene-related peptide and prostaglandin E-2 in response to noxious stimuli: evidence that nervi nervorum are nociceptors. Neuroscience. 1999;92:319–325
  19. Shacklock M. Clinical Neurodynamics. Edinburgh: Elsevier; 2005;

PII: S1360-8592(08)00034-X

doi: 10.1016/j.jbmt.2008.03.004

Journal of Bodywork and Movement Therapies
Volume 12, Issue 3 , Pages 185-190 , July 2008

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