Journal of Bodywork and Movement Therapies
Volume 10, Issue 3 , Pages 227-247 , July 2006

Aberrant learning in individuals who perform repetitive skilled hand movements: Focal hand dystonia—Part 1

  • Nancy N. Byl, Ph.D., P.T., F.A.P.T.A.

      Affiliations

    • Corresponding Author InformationTel.: +4154760736; fax: +4154763147.

Received 1 August 2005 ,Revised 25 November 2005 ,Accepted 1 December 2005.

References 

  1. Allard T, Clark SA, Jenkins WM, Merzenich MM. Reorganization of somatosensory area 3b representations in adult owl monkeys after digit syndactyly. Journal of Neurophysiology. 1991;66:1048–1058
  2. Altenmueller E. Causes and Cures of Focal Limb Dystonia in Musicians. London, UK: British Association of Perf. Art Medicine; 1988;
  3. Altenmueller E. Focal dystonia: advances in brain imaging and understanding of fine motor control in musicians. Hand Clinics. 2003;19(3):523–538xi
  4. Altenmuller E, Schurmann K, et al. Hits to the left, flops to the right: different emotions during listening to music are reflected in cortical lateralisation patterns. Neuropsychologia. 2002;40(13):2242–2256
  5. Bara-Jimenez W, Catalan MJ, et al. Abnormal somatosensory homunculus in dystonia of the hand. Annals of Neurology. 1998;44(5):828–831
  6. Bara-Jimenez W, Catalan MJ, et al. Spatial discrimination is abnormal in focal hand dystonia. Neurology. 2000;55(12):1869–1873
  7. Bara-Jimenez W, Shelton P, et al. Sensory discrimination capabilities in patients with focal hand dystonia. Annals of Neurology. 2000;47(3):377–380
  8. Barbe MF, Barr, AE, et al. Chronic repetitive reaching and grasping results in decreased motor performance and widespread tissue responses in a rat model of MSD. Journal of Orthopaedic Research. 2003;21(1):167–176
  9. Barr AE, Barbe MF. Pathophysiological tissue changes associated with repetitive movement: a review of the evidence. Physical Therapy. 2002;82(2):173–187
  10. Bell J, Bolanowski S, Holmes MH. The structure and function of pacinian corpuscles: a review. Progress in Neurobiology. 1994;79–128
  11. Black KJ, Ongur D, et al. Putamen volume in idiopathic focal dystonia. Neurology. 1998;51(3):819–824
  12. Blake DT, Byl NN, et al. Sensory representation abnormalities that parallel focal hand dystonia in a primate model. Somatosensory and Motor Research. 2002;19(4):347–357
  13. Blake DT, Byl NN, et al. Representation of the hand in the cerebral cortex. Behavioural and Brain Research. 2002;135(1–2):179–184
  14. Brin MF, Fahn S, Moskowitz C, et al. Localized injections of botulinum toxin for the treatment of focal dysstonia and nemifacial spasm. Movement Disorders. 1987;53:617–624
  15. Butterworth S, Francis S, et al. Abnormal cortical sensory activation in dystonia: an fMRI study. Movement Disorders. 2003;18(6):673–682
  16. Byl N. Focal hand dystonia may result from aberrant neuroplasticity. In:  Fahn S editors. Advances in Neurology Dystonia 4. vol. 94:2004;p. 19–27
  17. Byl N, Merzenich MM. Principles of Neuroplasticity: Implications for Neurorehabilitation and Learning. Woburn, MA: Butterworth-Heineman; 2001;(Chapter 26)
  18. Byl N, Hamati D, Melnick M, Wilson F, McKenzie A. The sensory consequences of repetitive strain injury in musicians: focal dystonia of the hand. Journal of Back and Musculoskeletal Rehabilitation. 1996;7:27–39
  19. Byl N, Wilson F, et al. Sensory dysfunction associated with repetitive strain injuries of tendonitis and focal hand dystonia; a comparative study. Journal of Orthopaedic and Sports Physical Therapy. 1996;23(4):234–244
  20. Byl N, McKenzie AA, Nagarajan SS. Effectiveness of Sensory Retraining: Three Case Studies of Patients with Focal Hand Dystonia. New Orleans, LA: Society for Neuroscience Annual Meeting November; 2000;
  21. Byl N, Nagarajan SS, Newton N, McKenzie AL. Effect of sensory discrimination training of structure and function in a musician with focal hand dystonia. Physical Therapy Case Reports. 2000;3:94–113
  22. Byl N, Nagarajan SS, Merzenich MM, Roberts T, McKenzie A. Correlation of clinical neuromusculoskeletal and central somatosensory performance: variability in controls and patients with severe and mild focal hand dystonia. Neural Plasticity. 2002;9(3):177–203
  23. Byl N, Nagarajan SS, McKenzie AA. Effect of Sensory Discrimination Training on Structure and Function in Patients with Focal Hand Dystonia: Three Case Studies. Archives of Physical Medicine and Rehabilitation. 2003;
  24. Byl NN, McKenzie A. Treatment effectiveness for patients with a history of repetitive hand use and focal hand dystonia: a planned, prospective follow-up study. Journal of Hand Therapy. 2000;13(4):289–301
  25. Byl NN, Melnick M. The neural consequences of repetition: clinical implications of a learning hypothesis. Journal of Hand Therapy. 1997;10(2):160–174
  26. Byl NN, Merzenich MM, et al. A primate genesis model of focal dystonia and repetitive strain injury: I. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys. Neurology. 1996;47(2):508–520
  27. Byl NN, Merzenich MM, et al. A primate model for studying focal dystonia and repetitive strain injury: effects on the primary somatosensory cortex. Physical Therapy. 1997;77(3):269–284
  28. Byl NN, McKenzie MM, et al. Differences in somatosensory hand organization in a healthy flutist and a flutist with focal hand dystonia: a case report. Journal of Hand Therapy. 2000;13(4):302–309
  29. Candia V, Elbert T, et al. Constraint-induced movement therapy for focal hand dystonia in musicians. Lancet. 1999;353(9146):42
  30. Candia V, Schafer T, et al. Sensory motor retuning: a behavioral treatment for focal hand dystonia of pianists and guitarists. Archives of Physical Medicine and Rehabilitation. 2002;83(10):1342–1348
  31. Candia V, Wienbruch C, et al. Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization. Proceedings of the National Academy of Sciences of USA. 2003;100(13):7942–7946
  32. Ceballos-Baummann A, Sheean G, Pasingham RE, Marsden CD, Brooks DJ. Cerebral activation with stereotyped writing in patients with writer's cramp before and after botulinum toxin treatment: a pet study. Neurology. 1995;45(Suppl.):393–396
  33. Charness ME. The relationsip between peripheral nerve injury and focal dystonia in musicians. American Academy of Neurology. 1993;162:21–27
  34. Charness ME, Ross MH, et al. Ulnar neuropathy and dystonic flexion of the fourth and fifth digits: clinical correlation in musicians. Muscle Nerve. 1996;19(4):431–437
  35. Chase, T., 1988. Positron emission tomographic studies of regional cerebral glucose metabolism in idiopathic dystonia. Advances in Neurology 50, 237–241.
  36. Chen R, Hallett M. Focal dystonia and repetitive motion disorders. Clinical Orthopaedics. 1998;(351):102–106
  37. Chen R, Tsai C, Lu C. Reciprocal inhibition in writers cramp. Movement Disorders. 1995;10:556–561
  38. Clark B, Barr AE, Safadi FF, Beitman L, Al-Shatti T, Amin M, et al. Median nerve trauma in a rat model of work-related musculoskeletal dirorder. Journal of Neurotrauma. 2003;
  39. Cohen L, Hallett M. Hand cramps: clinical features and electromyographic patterns in a focal dystonia. Neurology. 1988;38:1005–1012
  40. Cole R, Hallett M, et al. Double-blind trial of botulinum toxin for treatment of focal hand dystonia. Movement Disorders. 1995;10(4):466–471
  41. Defendini RFS. Magnetic resonance imaging of dystonic states. Advances in Neurology. 1988;50:265–275
  42. DeLong M. Primate models of movement disorders of basal ganglia origin. Trends in Neurosciences. 1990;13:281–285
  43. DeLong M, Crutcher MD, Georgopoulis AP. Primate globus pallidus and subthalamic nucleus: functional organization. Journal of Neurophysiology. 1985;53:530–543
  44. Deuschl G, Goddemeier C. Spontaneous and reflex activity of facial muscles in dystonia, Parkinson's disease, and in normal subjects. Journal of Neurology Neurosurger and Psychiatry. 1998;64(3):320–324
  45. Edgelow P. Thoracic Outlet Home Program Treatment Kit. Union City, CA: Edgelow Publishing; 1992;
  46. Elbert T, Candia V, et al. Alteration of digital representations in somatosensory cortex in focal hand dystonia. Neuroreport. 1998;9(16):3571–3575
  47. Elbert T, Flor H, et al. Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury. Neuroreport. 1994;5(18):2593–2597
  48. Elbert T, Pantev C, et al. Increased cortical representation of the fingers of the left hand in string players. Science. 1995;270(5234):305–307
  49. Elbert T, Sterr A, et al. Input-increase and input-decrease types of cortical reorganization after upper extremity amputation in humans. Experimental Brain Research. 1997;117(1):161–164
  50. Fahn S, Marsden CD. The Treatment of Dystonia. London: Butterworths; 1987;
  51. Fahn S, Hallett M, DeLong MR. Rating Scales: for Dystonia: Assessment of Reliability of Three Scales. Philadelphia, PA: Lippincott, Williams and Wilkins; 2004;
  52. Fernandez-Alvarez E, Garcia-Cazorla A, et al. Hand tremor and orofacial dyskinesia: clinical manifestations of glutaric aciduria type I in a young girl. Movement Disorders. 2003;18(9):1076–1079
  53. Fry H. Overuse syndromes in musicians 100 years ago: an historical review. Medical Journal of Australia. 1986;146:620–625
  54. Gasser T, Bove CM, et al. Haplotype analysis at the DYT1 locus in Ashkenazi Jewish patients with occupational hand dystonia. Movement Disorders. 1996;11(2):163–166
  55. Gasser T, Bove CM, Ozellius LJ, Hallett M, Charness ME, Hochberg FH, et al. Haplotype analysis at the DyT! locus in Ashkenazi Jewish patients with occupational hand dystonia. Movement Disorders. 1999;22:163–166
  56. Gelkopf M, Kreitler S, et al. Laughter in a psychiatric ward. Somatic, emotional, social, and clinical influences on schizophrenic patients. Journal of Nervous and Mental Disease. 1993;181(5):283–289
  57. Gerloff C, Corwell B, Chen R, Hallett M, Cohen LG. The role of the human motor cortex in the control of complex and simple finger movement sequences. Brain. 1998;121:1695–1709
  58. Gil Z, Connors BW, Amitai Y, Neuron A. Differential regulation of neocortical synapses by neuromodulators and activity. Neuron. 1997;19:679–686
  59. Gilman S, Junck L, Young A. Cerebral metabolic activity in diopathic dystonia studies with positron emission tomography. Advances in Neurology. 1988;50:231–236
  60. Groenwegen H, Berendse HW, Wolters JG, Lohman AH. The anatomical relationship of the prefontral cortex with the striatopallidal system, the thalamus and the amygdala: evidence for parallel organization. Progress in Brain Research. 1990;85:95–116
  61. Grunewald R, Yoneda Y, Shipman JM, Sagar HJ. Idiopathic focal dystonia: a disorder of muscle spindle afferent processing?. Brain. 1997;120:2179–2185
  62. Hasselmo M. Neuromodulation and cortical function; modeling the physiological basis of behavior. Behavioural and Brain Research. 1996;57:1–27
  63. Hebb D. The Organization of Behavior. New York: Wiley; 1949;
  64. Hochberg F, Hochberg NS. Occupational Cramps/Focal Dystonia. London: Martin Dunitz; 2000;(Chapter 14)
  65. Hochberg F, Harris S, et al. Occupational hand cramps: professional disorders of motor control. Hand Clinics. 1990;6(3):417–428
  66. Illarioshkin S, Markova ED, Slominsky PA, Miklena NI, Popovov SN, Limborska SA, et al. The GTP cyclohydrolase I gene in Russian families with dopa responsive dystonia. Archives of Neurology. 1988;55:789–792
  67. Jabusch H, Mueller SV, Altenmueller E. High Levels of Perfectionism and Anxiety in Musicians with Focal Dystonia. Atlanta, GA: International Dystonia Meeting; 2001;
  68. Jancovic J. Can peripheral trauma induce dystonia and other movement disorders? Yes. Movement Disorders. 2001;16:7–11
  69. Jankovic J, Shale H. Dystonia in musicians. Seminars in Neurology. 1989;9:131–135
  70. Jenkins WM, Merzenich MM. Reorganization of neocortical representations after brain injury: a neurophysiological model of the bases of recovery from stroke. Progress in Brain Research. 1987;71:249–266
  71. Jenkins WM, Merzenich MM, et al. Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. Journal of Neurophysiology. 1990;63(1):82–104
  72. Jenkins WM, Merzenich MM, et al. Neocortical representational dynamics in adult primates: implications for neuropsychology. Neuropsychologia. 1990;28(6):573–584
  73. Johanson R. Sensory Control of Dexterous Manipulation in Humans. San Diego, CA: Academic Press; 1996;
  74. Juliano, S.L., Ma, W., Eslin, D., 1991. Cholinergic depletion prevents expansion of topographic maps in somatosensory cortex. In: Proceedings of the National Academy of Sciences, USA 88, 780–784.
  75. Kaas JH, Nelson RJ, et al. Multiple representations of the body within the primary somatosensory cortex of primates. Science. 1979;204(4392):521–523
  76. Kahn KM, Cook JL, Bonar F, Harcourt P, Astrom M. Histopathology of common tendinopathies: update and implications for clinical management. Sports Medicine. 1999;27:393–408
  77. Kaji R, Rothwell JC, et al. Tonic vibration reflex and muscle afferent block in writer's cramp. Annals of Neurology. 1995;38(2):155–162
  78. Karne A. When practice makes perfect (Letter). Lancet. 1995;345:398–399
  79. Karp BI, Cole RA, et al. Long-term botulinum toxin treatment of focal hand dystonia. Neurology. 1994;44(1):70–76
  80. Kolle B. Psychological Approach to focal Dystonia in Musicians. London: Martin Dunitz; 2000;
  81. Leijnse JN. Anatomical factors predisposing to focal dystonia in the musician's hand-principles, theoretical examples, clinical significance. Journal of Biomechanis. 1997;30(7):659–669
  82. Lenz FA, Byl NN. Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (ventral caudal) in patients with dystonia. Journal of Neurophysiology. 1999;82(6):3204–3212
  83. Leube B, Rudnicki D, Ratzlaff T, Kessler KR, Benecke R. Idiopathic torsion dystonia: assignment of a gene to chromosome 18 p in a German family with adult onset, autosomal dominant inheritance and purely focal distribution. Human Molecular Genetics. 1996;5:1673–1677
  84. Lim VK, Altenmuller E, et al. Focal dystonia: current theories. Human Movement Science. 2001;20(6):875–914
  85. Liversedge LA, Sylvester JD. Conditioning Techniques in the Treatment of Writer's Cramp. Oxford, UK: Pergamon Press; 1960;
  86. Lockwood A. Medical Problems in Musicians. New England Journal of Medicine. 1989;320:221–227
  87. Mai N, Margiardt C. Treatment of Writers Cramp. Europia: Paris; 1994;
  88. Marsden CD, Sheehy MP. Writer's cramp. Trends in Neurosciences. 1990;13(4):148–153
  89. McKenzie AL, Nagarajan SS, et al. Somatosensory representation of the digits and clinical performance in patients with focal hand dystonia. American Journal of Physical Medicine and Rehabilitation. 2003;82(10):737–749
  90. Merzenich MM. Neural Representations, Experience, and Change. Cambridge, MA, USA: MIT Press; 1996;
  91. Merzenich MM, Jenkins WM. Reorganization of cortical representations of the hand following alterations of skin inputs induced by nerve injury, skin island transfers, and experience. Journal of Hand Therapy. 1993;6(2):89–104
  92. Merzenich MM, Jenkins WM. Cortical Plasticity, Learning, and Learning Dysfunction. New York, NY, USA: Addison-Wesley; 1995;
  93. Merzenich MM, Kaas JH, et al. Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation. Neuroscience. 1983;8(1):33–55
  94. Merzenich MM, Nelson RJ, et al. Somatosensory cortical map changes following digit amputation in adult monkeys. Journal of Comparative Neurology. 1984;224(4):591–605
  95. Merzenich MM, Recanzone GH, et al. Adaptive mechanisms in cortical networks underlying cortical contributions to learning and nondeclarative memory. Cold Spring Harbor Symposia on Quantitative Biology. 1990;55:873–887
  96. Merzenich M, Wright, B, et al. Cortical plasticity underlying perceptual, motor, and cognitive skill development: implications for neurorehabilitation. Cold Spring Harbor Symposia on Quantitative Biology. 1996;61:1–8
  97. Merzenich M, Tallal P, Peterson B, Miller SL, Jenkins WM. Some Neurological Principles Relevant to the Origins of-and the Cortical Plasticity Based Remediation of Language Learning Impairments. Springer: Berlin, Germany; 1999;
  98. Murase N, Kaji R, et al. Abnormal premovement gating of somatosensory input in writer's cramp. Brain. 2000;123:1813–1829
  99. Nagarajan SS, Blake DT, et al. Practice-related improvements in somatosensory interval discrimination are temporally specific but generalize across skin location, hemisphere, and modality. Journal of Neurosciences. 1998;18(4):1559–1570
  100. Nakashima K, Rothwell JC, Day BL, Thompson PD, Shannon K. Reciprocal inhibition between forearm muscles in patients with writer's cramp and other occupational cramps, symptomatic hemidystonia and hemiparesis due to stroke. Brain. 1989;112:681–697
  101. Naumann M, Reiners K. Long-latency reflexes of hand muscles in idiopathic focal dystonia and their modification by botulinum toxin. Brain. 1997;120(Part 3):409–416
  102. Newmark J, Hochberg G. Isolated painless manual incoordination in musicians. Journal of Neurology Neurosurgery and Psychiatry. 1987;50:291–295
  103. Nudo RJ. Adaptive plasticity in motor cortex: implications for rehabilitation after brain injury. Journal of Rehabilitation Medicine. 2003;(Suppl. 41):7–10
  104. Nudo RJ, Milliken GW. Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. Journal of Neurophysiology. 1996;75(5):2144–2149
  105. Nudo RJ, Milliken GW, et al. Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. Journal of Neurosciences. 1996;16(2):785–807
  106. Nudo RJ, Wise BM, et al. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science. 1996;272(5269):1791–1794
  107. Nudo RJ, Plautz EJ, et al. Role of adaptive plasticity in recovery of function after damage to motor cortex. Muscle Nerve. 2001;24(8):1000–1019
  108. Ozelius L, Hewett JW, Page CE, Brissman SB, Kramer PL, Shalish C, et al. The early onset of torsion dystonia gene (DYT1) encodes an ATD binding protein nature. MGenetics. 1997;40:40–48
  109. Panizza M, Hallett M, Nilsson J. Reciprocal inhibition in patients with hand cramps. Neurology. 1989;39:85–89
  110. Panizza M, Lelli S, Nilsson J, Hallet M. H reflex recovery curve and reciprocal inhibition of H reflex in different kinds of dystonia. Neurology. 1990;40:824–828
  111. Pascual-Leone A. The brain that plays music and is changed by it. Annals of New York Academy of Sciences. 2001;930:315–329
  112. Pascual-Leone A, Dang N, Cohen LG, Brasil-Neto JP, Cammarota A, Hallett M. Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. Journal of Neurophysiology. 1995;74:1037–1045
  113. Penfield WRT. The Cerebral Cortex of Man: A Clinical Study of Localization of Function. New York, NY: MacMillan Publishing; 1950;
  114. Perlmutter JS, Stambuk MK, et al. Decreased [18F]spiperone binding in putamen in idiopathic focal dystonia. Journal of Neurosciences. 1997;17(2):843–850
  115. Peterson B, Merzenich MM. MAP: a Macintosh program for generating categorical maps applied to cortical mapping. Journal of Neuroscience Methods. 1995;57:133–144
  116. Pitner MA. Pathophysiology of overuse injuries in the hand and wrist. Hand Clinics. 1990;6(3):355–364
  117. Priori A, Pesenti A, et al. Limb immobilization for the treatment of focal occupational dystonia. Neurology. 2001;57(3):405–409
  118. Pullman SL, Greene P, et al. Approach to the treatment of limb disorders with botulinum toxin A. Experience with 187 patients. Archives of Neurology. 1996;53(7):617–624
  119. Quartarone A, Girlanda P, et al. Focal hand dystonia in a patient with thoracic outlet syndrome. Journal of Neurology Neurosurgery and Psychiatry. 1998;65(2):272–274
  120. Recanzone GH, Allard TT, et al. Receptive-field changes induced by peripheral nerve stimulation in SI of adult cats. Journal of Neurophysiology. 1990;63(5):1213–1225
  121. Recanzone GH, Jenkins WM, et al. Progressive improvement in discriminative abilities in adult owl monkeys performing a tactile frequency discrimination task. Journal of Neurophysiology. 1992;67(5):1015–1030
  122. Recanzone GH, Merzenich MM, et al. Expansion of the cortical representation of a specific skin field in primary somatosensory cortex by intracortical microstimulation. Cerebral Cortex. 1992;2(3):181–196
  123. Recanzone GH, Merzenich MM, et al. Frequency discrimination training engaging a restricted skin surface results in an emergence of a cutaneous response zone in cortical area 3a. Journal of Neurophysiology. 1992;67(5):1057–1070
  124. Recanzone GH, Merzenich MM, et al. Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. Journal of Neurophysiology. 1992;67(5):1031–1056
  125. Recanzone GH, Merzenich MM, et al. Changes in the distributed temporal response properties of SI cortical neurons reflect improvements in performance on a temporally based tactile discrimination task. Journal of Neurophysiology. 1992;67(5):1071–1091
  126. Rijntjes MDC, Buchel C, Kiebel S, Frackowiak RS, Weiller C. A blueprint for movement: functional and anatomical representations in the human motor system. Journal of Neurosciences. 1999;19:8043–8048
  127. Roberts T, Rowley H, Kucharczyk J. Applications of magnetic source imaging to presurgical brain mapping. Neuroimaging Clinics of North American. 1995;5(251–266):
  128. Rosenbaum F, Jankovic J. Focal task-specific tremor and dystonia; categorization of occupational movement disorders. Neurology. 1988;38:522–527
  129. Rothwell JC. Pathophysiology of dystonias. Advances in Neurology. 1983;39:851–863
  130. Salmon PS, Lombart KG, Berenson G. Performance impairments, injuries, and stress tardiness in a sample of keyboard and other instrumentalists. Medical Problems of Performing Artists. 1995;10:140–146
  131. Sanger TD, Merzenich MM. Computational model of the role of sensory disorganization in focal task-specific dystonia. Journal of Neurophysiology. 2000;84(5):2458–2464
  132. Sheehy MP, Marsden CD. Writers’ cramp—a focal dystonia. Brain. 1982;105(Part 3):461–480
  133. Sherrington C. The Integrative Action of the Nervous System. New Haven, Connecticut, USA: Yale University Press; 1906;
  134. Spengler F, Roberts TP, et al. Learning transfer and neuronal plasticity in humans trained in tactile discrimination. Neuroscience Letters. 1997;232(3):151–154
  135. Sterr A, Muller MM, Elbert T, Rockstroh B, Pantev C, Taub E. Changed perceptions in Braille readers. Nature. 1998;391:135–136
  136. Stock SR. Workplace ergonomic factors and the development of musculoskeletal disorders of the neck and upper limbs: a meta-analysis. American Journal of Industrial Medicine. 1991;19(1):87–107
  137. Stryker M, Jenkins WM, Merzenich MM. Anesthetic state does not affect the map of the hand representation within are 3b somatosensory cortex in owl monkeys. Journal of Comparative Neurology. 1987;258:297–303
  138. Tempel L, Perlmutter JS. Abnormal cortical responses in patients with writer's cramp. Neurology. 1993;43:2252–2257
  139. Tinazzi M, Frasson E, Bertolasi L, Fiaschi A, Aglioti S. Temporal discrimination of somesthetic stimuli is impaired in dystonic patients. Neuro-Report. 1999;10:1547–1550
  140. Tinazzi M, Rosso T, et al. Role of the somatosensory system in primary dystonia. Movement Disorders. 2003;18(6):605–622
  141. Topp KS, Byl NN. Movement dysfunction following repetitive hand opening and closing: anatomical analysis in Owl monkeys. Movement Disorders. 1999;14(2):295–306
  142. Toro C, Deuschl T, et al. Movement-related electroencephalographic desynchronization in patients with hand cramps: evidence for motor cortical involvement in focal dystonia. Annals of Neurology. 2000;47(4):456–461
  143. Tsui J, Bhatt M, Clane S, Clane D. Botulinum toxin in the treatment of writer's cramp: a double-blind study. Neurolgy. 1993;43:183–185
  144. Tubiana R. Focal Dystonia. Incidence: Classification of Severity and Results of Therapy. London, UK: Martin Dunitz Ltd.; 1998;
  145. Tubiana R. Musician's focal dystonia. Hand Clinics. 2003;19(2):303–308vii
  146. Tubiana R, Chamagne P. Occupational “cramps” of the upper limb. Ann Chir. Main. 1983;2(2):134–142
  147. Utti R, Vingerhoets JG, Tsui JKC. Limb Dystonia. New York: Marcel Dekker, Inc.; 1995;
  148. van Hilten BJ, van de Beek WJ, et al. Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. New England Journal of Medicine. 2000;343(9):625–630
  149. Viikari-Juntura E, Silverstein B. Role of physical load factors in carpal tunnel syndrome. Scandinavia Journal of Work Environment and Health. 1999;25(3):163–185
  150. Wall JT, Felleman DJ, et al. Recovery of normal topography in the somatosensory cortex of monkeys after nerve crush and regeneration. Science. 1983;221(4612):771–773
  151. Wall JT, Huerta MF, et al. Changes in the cortical map of the hand following postnatal median nerve injury in monkeys: modification of somatotopic aggregates. Journal of Neurosciences. 1992;12(9):3445–3455
  152. Wang X, Merzenich MM, Sameshima K, Jenkins WM. Afferent input integration and segregation in learning are input timing dependent. Neuroscience Abstracts. 1994;20(20):1427
  153. Wang X, Merzenich, MM, et al. Remodelling of hand representation in adult cortex determined by timing of tactile stimulation. Nature. 1995;378(6552):71–75
  154. Weiner W. Can peripheral trauma induce dystonia? No. Movement Disorders. 2001;16:13–22
  155. Wilson FR, Wagner C, et al. Biomechanical abnormalities in musicians with occupational cramp/focal dystonia. Journal of Hand Therapy. 1993;6(4):298–307
  156. Woolsey C. Organization of Somatic Sensory and Motor Areas of the Cerebral Cortex. Madison, WI: University of Wisconsin Press; 1958;
  157. Xerri C, Coq JO, et al. Experience-induced plasticity of cutaneous maps in the primary somatosensory cortex of adult monkeys and rats. Journal of Physiology, Paris. 1996;90(3–4):277–287
  158. Xerri C, Merzenich MM, et al. Representational plasticity in cortical area 3b paralleling tactual-motor skill acquisition in adult monkeys. Cerebral Cortex. 1999;9(3):264–276
  159. Yang MS, Tseng CK, et al. The functional assessment of chronic pain patients activity of daily living and psychosocial disability. Gaoxiong Yi Xue Ke Xue Za Zhi. 1992;8(10):552–561
  160. Zirh T, Reich SG, Perry V. Thalamic single neuron and electromyographic activities in patients with dystonia. Advances in Neurology. 1998;78:27–32

PII: S1360-8592(05)00157-9

doi: 10.1016/j.jbmt.2005.12.001

Journal of Bodywork and Movement Therapies
Volume 10, Issue 3 , Pages 227-247 , July 2006

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